The Science of Kambo
Application​
Kambo is applied transdermally through small points on the skin known as “gates.”
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First, small superficial burns are made on the top layer of the skin, usually on the shoulder, arm, or leg.
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The secretion from the frog is reconstituted with saliva to activate the peptides.
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The practitioner then applies small dots of the secretion to the open gates.
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Within seconds, the peptides enter the lymphatic system and circulatory system, bypassing the digestive tract.​
The Peptides
Kambo is rich in bioactive peptides, small chains of amino acids that act as messengers and modulators throughout the body. These peptides interact with receptors in the brain, immune system, nervous system, and gut, offering a wide range of therapeutic effects.
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Below is a breakdown of some of the most powerful peptides found in the secretion of the Phyllomedusa bicolor frog:
Phyllomedusin
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Stimulates deep detoxification by triggering strong muscular contractions in the digestive system.
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Increases secretion from salivary glands, stomach, intestines, pancreas, and gallbladder.
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Responsible for the characteristic purge experienced during a Kambo session.
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Caeruleins & Sauvagines
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Stimulate smooth muscles in the colon and urinary bladder.
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Lower blood pressure while increasing heart rate (tachycardia).
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Activate the adrenal cortex and pituitary gland, enhancing:
- Sensory perception - Pain resistance - Fatigue reduction​
- Physical stamina - Stress resilience
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​ Dermorphin & Deltorphin
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Bind to mu- and delta-opioid receptors, offering profound pain relief, tranquility, and mood elevation.
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Soothe the nervous system, reduce anxiety, and promote emotional regulation.
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Enhance neuroplasticity and support emotional recovery after deep release.
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Selectively bind to opiate delta receptors in the brain.
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Phyllokinin & Phyllomedusins
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Dilate blood vessels and increase permeability of the blood-brain barrier, allowing deeper penetration of other peptides.
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Allow deeper access for other peptides to the brain and central nervous system.
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Possesses antimicrobial and antifungal properties.
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Support detox and nutrient delivery through improved circulation.​
​ Bombesins
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Stimulate the digestive system, enhancing enzyme and bile secretion.
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Regulate appetite and gut-brain communication.
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Improve nutrient absorption and metabolism.
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Support detox pathways through gentle stimulation of intestinal movement
Adenoregulin
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Targets adenosine receptors, critical for regulating cellular energy.
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Has therapeutic benefits for:
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Depression
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Cognitive decline
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Stroke recovery
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Neurodegenerative diseases like Parkinson’s and Alzheimer’s.
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Antimicrobial Peptides
(Dermaseptins, Adenoregulins, Plasticins, Phylloseptins)
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Protect the frog’s skin from microbial invasion—and offer similar immune support in humans.
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Dermaseptin B2 and B3 have demonstrated effectiveness in killing certain cancer cells.
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Bradykinins​
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Contribute to inflammatory responses and the regulation of pain.
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Promote vasodilation — increasing blood flow and oxygen delivery throughout the body.
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Aid in detoxification by enhancing circulation.​
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Support tissue repair and cellular regeneration.​
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Ceruleins​
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Stimulate gastric, bile, and pancreatic secretions, aiding in deep internal cleansing.
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Relax and contract smooth muscle tissue, supporting digestion and circulation.
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Assist in purging and clearing stored toxicity.
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Regulate heart rhythm and blood pressure balance.
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Tryptophyllins
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A group of neuropeptides which influence brain function.
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Modulate brain chemistry and neurotransmitter activity.
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Support emotional balance and cognitive function.
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Encourage expanded states of awareness and mental clarity.
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Help regulate stress response and mood stabilization.
These peptides work in harmony with the Spirit of Kambo to promote deep, whole-body healing — cleansing and detoxifying the physical body, fortifying the immune system, restoring emotional and energetic balance, supporting mental clarity, and realigning the spirit with its natural state of harmony and vitality.